Publications

all Publications


Mure, L.S., Hatori, M., Ruda, K., Benegiamo, G., Demas, J., Panda, S. Sustained Melanopsin Photoresponse Is Supported by Specific Roles of β-Arrestin 1 and 2 in Deactivation and Regeneration of Photopigment. (2018) Cell Rep. 25(9):2497-2509.e4. DOI: 10.1016/j.celrep.2018.11.008

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Chaix, A., Lin, T., Le, H.D., Chang, M.W., Panda, S. Time-Restricted Feeding Prevents Obesity and Metabolic Syndrome in Mice Lacking a Circadian Clock (2018) Cell Metabolism. In Press. DOI: 10.1016/j.cmet.2018.08.004

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Zarrinpar, A., Chaix, A., Xu, Z.Z., Chang, M.W., Marotz, C.A., Saghatelian, A., Knight, R., Panda, S. Antibiotic-induced microbiome depletion alters metabolic homeostasis by affecting gut signaling and colonic metabolism. (2018) Nat Commun. 9(1):2872. DOI: 10.1038/s41467-018-05336-9

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Sulli, G., Manoogian, E.N.C., Taub, P.R., Panda, S. Training the Circadian Clock, Clocking the Drugs, and Drugging the Clock to Prevent, Manage, and Treat Chronic Diseases. (2018) Trends Pharmacol. Sci. DOI: 10.1016/j.tips.2018.07.003

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Gabel, K., Hoddy, K.K., Haggerty, N., Song, J., Kroeger, C.M., Trepanowski, J.F., Panda, S., Varady, K.A. Effects of 8-hour time restricted feeding on body weight and metabolic disease risk factors in obese adults: A pilot study. (2018) Nutr Healthy Aging. 4(4):345-353. DOI: 10.3233/NHA-170036

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Mure, L.S., Le, H.D., Benegiamo, G., Chang, M.W., Rios, L., Jillani, N., Ngotho, M., Kariuki, T., Dkhissi-Benyahya, O., Cooper, H.M., Panda, S. Diurnal transcriptome atlas of a primate across major neural and peripheral tissues. (2018) Science. DOI: 10.1126/science.aao0318

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Sulli, G., Rommel, A., Wang, X., Kolar, M.J., Puca, F., Saghatelian, A., Plikus, M.V., Verma, I.M., Panda, S. Pharmacological activation of REV-ERBs is lethal in cancer and oncogene-induced senescence. (2018) Nature. DOI: 10.1038/nature25170

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Benegiamo, G., Mure, L.S., Erikson, G., Le, H.D., Moriggi, E., Brown, S.A., Panda, S. The RNA-Binding Protein NONO Coordinates Hepatic Adaptation to Feeding. (2018) Cell Metab. DOI: 10.1016/j.cmet.2017.12.010

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Lunn, R.M., Blask, D.E., Coogan, A.N., Figueiro, M.G., Gorman, M.R., Hall, J.E., Hansen, J., Nelson, R.J., Panda, S., Smolensky, M.H., Stevens, R.G., Turek, F.W., Vermeulen, R., Carreón, T., Caruso, C.C., Lawson, C.C., Thayer, K.A., Twery, M.J., Ewens, A.D., Garner, S.C., Schwingl, P.J., Boyd, W.A. Health consequences of electric lighting practices in the modern world: A report on the National Toxicology Program’s workshop on shift work at night, artificial light at night, and circadian disrupti (2017) Sci. Total Environ. 607-608:1073-1084. DOI: 10.1016/j.scitotenv.2017.07.056

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Manoogian, E.N.C., Panda, S. Circadian rhythms, time-restricted feeding, and healthy aging. (2017) Ageing Res. Rev. 39:59-67. DOI: 10.1016/j.arr.2016.12.006

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Hatori, M., Gronfier, C., Van Gelder, R.N., Bernstein, P.S., Carreras, J., Panda, S., Marks, F., Sliney, D., Hunt, C.E., Hirota, T., Furukawa, T., Tsubota, K. Global rise of potential health hazards caused by blue light-induced circadian disruption in modern aging societies. (2017) NPJ Aging Mech Dis. 3:9. DOI: 10.1038/s41514-017-0010-2

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Melkani, G.C., Panda, S. Time-restricted feeding for prevention and treatment of cardiometabolic disorders. (2017) J. Physiol. (Lond.). 595(12):3691-3700. DOI: 10.1113/JP273094

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Gupta, N.J., Kumar, V., Panda, S. A camera-phone based study reveals erratic eating pattern and disrupted daily eating-fasting cycle among adults in India. (2017) PLoS ONE. 12(3):e0172852. DOI: 10.1371/journal.pone.0172852

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Kofuji, P., Mure, L.S., Massman, L.J., Purrier, N., Panda, S., Engeland, W.C. Intrinsically Photosensitive Retinal Ganglion Cells (ipRGCs) Are Necessary for Light Entrainment of Peripheral Clocks. (2016) PLoS ONE. 11(12):e0168651. DOI: 10.1371/journal.pone.0168651

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Panda, S. Circadian physiology of metabolism. (2016) Science. 354(6315):1008-1015. DOI: 10.1126/science.aah4967

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Chaix, A., Zarrinpar, A., Panda, S. The circadian coordination of cell biology. (2016) J. Cell Biol. 215(1):15-25. DOI: 10.1083/jcb.201603076

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Longo, V.D., Panda, S. Fasting, Circadian Rhythms, and Time-Restricted Feeding in Healthy Lifespan. (2016) Cell Metab. 23(6):1048-1059. DOI: 10.1016/j.cmet.2016.06.001

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Mure, L.S., Hatori, M., Zhu, Q., Demas, J., Kim, I.M., Nayak, S.K., Panda, S. Melanopsin-Encoded Response Properties of Intrinsically Photosensitive Retinal Ganglion Cells. (2016) Neuron. 90(5):1016-27. DOI: 10.1016/j.neuron.2016.04.016

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Chaix, A., Panda, S. Ketone Bodies Signal Opportunistic Food-Seeking Activity. (2016) Trends Endocrinol. Metab. 27(6):350-2. DOI: 10.1016/j.tem.2016.03.014

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Manoogian, E.N., Panda, S. Circadian clock, nutrient quality, and eating pattern tune diurnal rhythms in the mitochondrial proteome. (2016) Proc. Natl. Acad. Sci. U.S.A. 113(12):3127-9. DOI: 10.1073/pnas.1601786113


Zarrinpar, A., Chaix, A., Panda, S. Daily Eating Patterns and Their Impact on Health and Disease. (2016) Trends Endocrinol. Metab. 27(2):69-83. DOI: 10.1016/j.tem.2015.11.007

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Benegiamo, G., Brown, S.A., Panda, S. RNA Dynamics in the Control of Circadian Rhythm. (2016) Adv. Exp. Med. Biol. 907:107-22. DOI: 10.1007/978-3-319-29073-7_5

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Arble, D.M., Bass, J., Behn, C.D., Butler, M.P., Challet, E., Czeisler, C., Depner, C.M., Elmquist, J., Franken, P., Grandner, M.A., Hanlon, E.C., Keene, A.C., Joyner, M.J., Karatsoreos, I., Kern, P.A., Klein, S., Morris, C.J., Pack, A.I., Panda, S., Ptacek, L.J., Punjabi, N.M., Sassone-Corsi, P., Scheer, F.A., Saxena, R., Seaquest, E.R., Thimgan, M.S., Van Cauter, E., Wright, K.P. Impact of Sleep and Circadian Disruption on Energy Balance and Diabetes: A Summary of Workshop Discussions. (2015) Sleep. 38(12):1849-60. DOI: 10.5665/sleep.5226

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Gill, S., Panda, S. A Smartphone App Reveals Erratic Diurnal Eating Patterns in Humans that Can Be Modulated for Health Benefits. (2015) Cell Metab. 22(5):789-98. DOI: 10.1016/j.cmet.2015.09.005

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Singh, D., Trivedi, A.K., Rani, S., Panda, S., Kumar, V. Circadian timing in central and peripheral tissues in a migratory songbird: dependence on annual life-history states. (2015) FASEB J. 29(10):4248-55. DOI: 10.1096/fj.15-275339

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Gill, S., Le, H.D., Melkani, G.C., Panda, S. Time-restricted feeding attenuates age-related cardiac decline in Drosophila. (2015) Science. 347(6227):1265-9. DOI: 10.1126/science.1256682

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Bushong, E.A., Johnson, D.D., Kim, K.Y., Terada, M., Hatori, M., Peltier, S.T., Panda, S., Merkle, A., Ellisman, M.H. X-ray microscopy as an approach to increasing accuracy and efficiency of serial block-face imaging for correlated light and electron microscopy of biological specimens. (2015) Microsc. Microanal. 21(1):231-8. DOI: 10.1017/S1431927614013579

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Hatori, M., Panda, S. Response of peripheral rhythms to the timing of food intake. (2015) Meth. Enzymol. 552:145-61. DOI: 10.1016/bs.mie.2014.10.027

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Zarrinpar, A., Chaix, A., Yooseph, S., Panda, S. Diet and feeding pattern affect the diurnal dynamics of the gut microbiome. (2014) Cell Metab. 20(6):1006-17. DOI: 10.1016/j.cmet.2014.11.008

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Chaix, A., Zarrinpar, A., Miu, P., Panda, S. Time-restricted feeding is a preventative and therapeutic intervention against diverse nutritional challenges. (2014) Cell Metab. 20(6):991-1005. DOI: 10.1016/j.cmet.2014.11.001

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Perez, A.J., Seyedhosseini, M., Deerinck, T.J., Bushong, E.A., Panda, S., Tasdizen, T., Ellisman, M.H. A workflow for the automatic segmentation of organelles in electron microscopy image stacks. (2014) Front Neuroanat. 8:126. DOI: 10.3389/fnana.2014.00126

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Mattson, M.P., Allison, D.B., Fontana, L., Harvie, M., Longo, V.D., Malaisse, W.J., Mosley, M., Notterpek, L., Ravussin, E., Scheer, F.A., Seyfried, T.N., Varady, K.A., Panda, S. Meal frequency and timing in health and disease. (2014) Proc. Natl. Acad. Sci. U.S.A. 111(47):16647-53. DOI: 10.1073/pnas.1413965111

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Pieraut, S., Gounko, N., Sando, R., Dang, W., Rebboah, E., Panda, S., Madisen, L., Zeng, H., Maximov, A. Experience-dependent remodeling of basket cell networks in the dentate gyrus. (2014) Neuron. 84(1):107-22. DOI: 10.1016/j.neuron.2014.09.012

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Mao, C.A., Li, H., Zhang, Z., Kiyama, T., Panda, S., Hattar, S., Ribelayga, C.P., Mills, S.L., Wang, S.W. T-box transcription regulator Tbr2 is essential for the formation and maintenance of Opn4/melanopsin-expressing intrinsically photosensitive retinal ganglion cells. (2014) J. Neurosci. 34(39):13083-95. DOI: 10.1523/JNEUROSCI.1027-14.2014

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Hatori, M., Gill, S., Mure, L.S., Goulding, M., O’Leary, D.D., Panda, S. Lhx1 maintains synchrony among circadian oscillator neurons of the SCN. (2014) Elife. 3:e03357. DOI: 10.7554/eLife.03357

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Liu, Z., Huang, M., Wu, X., Shi, G., Xing, L., Dong, Z., Qu, Z., Yan, J., Yang, L., Panda, S., Xu, Y. PER1 phosphorylation specifies feeding rhythm in mice. (2014) Cell Rep. 7(5):1509-20. DOI: 10.1016/j.celrep.2014.04.032

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Hatori, M., Panda, S. Nucleosome dynamics regulate Neurospora circadian clock. (2013) EMBO Rep. 14(10):854-5. DOI: 10.1038/embor.2013.143


Jones, K.A., Hatori, M., Mure, L.S., Bramley, J.R., Artymyshyn, R., Hong, S.P., Marzabadi, M., Zhong, H., Sprouse, J., Zhu, Q., Hartwick, A.T., Sollars, P.J., Pickard, G.E., Panda, S. Small-molecule antagonists of melanopsin-mediated phototransduction. (2013) Nat. Chem. Biol. 9(10):630-5. DOI: 10.1038/nchembio.1333

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Hardin, P.E., Panda, S. Circadian timekeeping and output mechanisms in animals. (2013) Curr. Opin. Neurobiol. 23(5):724-31. DOI: 10.1016/j.conb.2013.02.018

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Fischer, R.M., Fontinha, B.M., Kirchmaier, S., Steger, J., Bloch, S., Inoue, D., Panda, S., Rumpel, S., Tessmar-Raible, K. Co-expression of VAL- and TMT-opsins uncovers ancient photosensory interneurons and motorneurons in the vertebrate brain. (2013) PLoS Biol. 11(6):e1001585. DOI: 10.1371/journal.pbio.1001585

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Plikus, M.V., Vollmers, C., de la Cruz, D., Chaix, A., Ramos, R., Panda, S., Chuong, C.M. Local circadian clock gates cell cycle progression of transient amplifying cells during regenerative hair cycling. (2013) Proc. Natl. Acad. Sci. U.S.A. 110(23):E2106-15. DOI: 10.1073/pnas.1215935110

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Clark, D.D., Gorman, M.R., Hatori, M., Meadows, J.D., Panda, S., Mellon, P.L. Aberrant development of the suprachiasmatic nucleus and circadian rhythms in mice lacking the homeodomain protein Six6. (2013) J. Biol. Rhythms. 28(1):15-25. DOI: 10.1177/0748730412468084

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Vollmers, C., Schmitz, R.J., Nathanson, J., Yeo, G., Ecker, J.R., Panda, S. Circadian oscillations of protein-coding and regulatory RNAs in a highly dynamic mammalian liver epigenome. (2012) Cell Metab. 16(6):833-45. DOI: 10.1016/j.cmet.2012.11.004

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Mure, L.S., Panda, S. Fear of the light or need for action: the IGL will judge. (2012) Neuron. 75(4):546-8. DOI: 10.1016/j.neuron.2012.08.012

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Narasimamurthy, R., Hatori, M., Nayak, S.K., Liu, F., Panda, S., Verma, I.M. Circadian clock protein cryptochrome regulates the expression of proinflammatory cytokines. (2012) Proc. Natl. Acad. Sci. U.S.A. 109(31):12662-7. DOI: 10.1073/pnas.1209965109

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Hatori, M., Vollmers, C., Zarrinpar, A., DiTacchio, L., Bushong, E.A., Gill, S., Leblanc, M., Chaix, A., Joens, M., Fitzpatrick, J.A., Ellisman, M.H., Panda, S. Time-restricted feeding without reducing caloric intake prevents metabolic diseases in mice fed a high-fat diet. (2012) Cell Metab. 15(6):848-60. DOI: 10.1016/j.cmet.2012.04.019

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Cho, H., Zhao, X., Hatori, M., Yu, R.T., Barish, G.D., Lam, M.T., Chong, L.W., DiTacchio, L., Atkins, A.R., Glass, C.K., Liddle, C., Auwerx, J., Downes, M., Panda, S., Evans, R.M. Regulation of circadian behaviour and metabolism by REV-ERB-α and REV-ERB-β. (2012) Nature. 485(7396):123-7. DOI: 10.1038/nature11048

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Siegert, S., Cabuy, E., Scherf, B.G., Kohler, H., Panda, S., Le, Y.Z., Fehling, H.J., Gaidatzis, D., Stadler, M.B., Roska, B. Transcriptional code and disease map for adult retinal cell types. (2012) Nat. Neurosci. 15(3):487-95, S1-2. DOI: 10.1038/nn.3032

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DiTacchio, L., Le, H.D., Vollmers, C., Hatori, M., Witcher, M., Secombe, J., Panda, S. Histone lysine demethylase JARID1a activates CLOCK-BMAL1 and influences the circadian clock. (2011) Science. 333(6051):1881-5. DOI: 10.1126/science.1206022

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Ma, D., Panda, S., Lin, J.D. Temporal orchestration of circadian autophagy rhythm by C/EBPβ. (2011) EMBO J. 30(22):4642-51. DOI: 10.1038/emboj.2011.322

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Park, D., Hadžić, T., Yin, P., Rusch, J., Abruzzi, K., Rosbash, M., Skeath, J.B., Panda, S., Sweedler, J.V., Taghert, P.H. Molecular organization of Drosophila neuroendocrine cells by Dimmed. (2011) Curr. Biol. 21(18):1515-24. DOI: 10.1016/j.cub.2011.08.015

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Gill, S., Panda, S. Feeding mistiming decreases reproductive fitness in flies. (2011) Cell Metab. 13(6):613-4. DOI: 10.1016/j.cmet.2011.05.003

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Hatori, M., Panda, S. CRY links the circadian clock and CREB-mediated gluconeogenesis. (2010) Cell Res. 20(12):1285-8. DOI: 10.1038/cr.2010.152


Brown, T.M., Gias, C., Hatori, M., Keding, S.R., Semo, M., Coffey, P.J., Gigg, J., Piggins, H.D., Panda, S., Lucas, R.J. Melanopsin contributions to irradiance coding in the thalamo-cortical visual system. (2010) PLoS Biol. 8(12):e1000558. DOI: 10.1371/journal.pbio.1000558

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Jones, M.A., Covington, M.F., DiTacchio, L., Vollmers, C., Panda, S., Harmer, S.L. Jumonji domain protein JMJD5 functions in both the plant and human circadian systems. (2010) Proc. Natl. Acad. Sci. U.S.A. 107(50):21623-8. DOI: 10.1073/pnas.1014204108

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Hatori, M., Panda, S. The emerging roles of melanopsin in behavioral adaptation to light. (2010) Trends Mol Med. 16(10):435-46. DOI: 10.1016/j.molmed.2010.07.005

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Vollmers, C., Gill, S., DiTacchio, L., Pulivarthy, S.R., Le, H.D., Panda, S. Time of feeding and the intrinsic circadian clock drive rhythms in hepatic gene expression. (2009) Proc. Natl. Acad. Sci. U.S.A. 106(50):21453-8. DOI: 10.1073/pnas.0909591106

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Lamia, K.A., Sachdeva, U.M., DiTacchio, L., Williams, E.C., Alvarez, J.G., Egan, D.F., Vasquez, D.S., Juguilon, H., Panda, S., Shaw, R.J., Thompson, C.B., Evans, R.M. AMPK regulates the circadian clock by cryptochrome phosphorylation and degradation. (2009) Science. 326(5951):437-40. DOI: 10.1126/science.1172156

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Hitomi, K., DiTacchio, L., Arvai, A.S., Yamamoto, J., Kim, S.T., Todo, T., Tainer, J.A., Iwai, S., Panda, S., Getzoff, E.D. Functional motifs in the (6-4) photolyase crystal structure make a comparative framework for DNA repair photolyases and clock cryptochromes. (2009) Proc. Natl. Acad. Sci. U.S.A. 106(17):6962-7. DOI: 10.1073/pnas.0809180106

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Hughes, M.E., DiTacchio, L., Hayes, K.R., Vollmers, C., Pulivarthy, S., Baggs, J.E., Panda, S., Hogenesch, J.B. Harmonics of circadian gene transcription in mammals. (2009) PLoS Genet. 5(4):e1000442. DOI: 10.1371/journal.pgen.1000442

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Baggs, J.E., Price, T.S., DiTacchio, L., Panda, S., Fitzgerald, G.A., Hogenesch, J.B. Network features of the mammalian circadian clock. (2009) PLoS Biol. 7(3):e52. DOI: 10.1371/journal.pbio.1000052

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Vollmers, C., Panda, S., DiTacchio, L. A high-throughput assay for siRNA-based circadian screens in human U2OS cells. (2008) PLoS ONE. 3(10):e3457. DOI: 10.1371/journal.pone.0003457

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Lin, B., Koizumi, A., Tanaka, N., Panda, S., Masland, R.H. Restoration of visual function in retinal degeneration mice by ectopic expression of melanopsin. (2008) Proc. Natl. Acad. Sci. U.S.A. 105(41):16009-14. DOI: 10.1073/pnas.0806114105

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Hatori, M., Le, H., Vollmers, C., Keding, S.R., Tanaka, N., Buch, T., Waisman, A., Schmedt, C., Jegla, T., Panda, S. Inducible ablation of melanopsin-expressing retinal ganglion cells reveals their central role in non-image forming visual responses. (2008) PLoS ONE. 3(6):e2451. DOI: 10.1371/journal.pone.0002451

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Pulivarthy, S.R., Tanaka, N., Welsh, D.K., De Haro, L., Verma, I.M., Panda, S. Reciprocity between phase shifts and amplitude changes in the mammalian circadian clock. (2007) Proc. Natl. Acad. Sci. U.S.A. 104(51):20356-61. DOI: 10.1073/pnas.0708877104

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Panda, S. Multiple photopigments entrain the Mammalian circadian oscillator. (2007) Neuron. 53(5):619-21. DOI: 10.1016/j.neuron.2007.02.017

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Miller, B.H., McDearmon, E.L., Panda, S., Hayes, K.R., Zhang, J., Andrews, J.L., Antoch, M.P., Walker, J.R., Esser, K.A., Hogenesch, J.B., Takahashi, J.S. Circadian and CLOCK-controlled regulation of the mouse transcriptome and cell proliferation. (2007) Proc. Natl. Acad. Sci. U.S.A. 104(9):3342-7. DOI: 10.1073/pnas.0611724104

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De Haro, L., Panda, S. Systems biology of circadian rhythms: an outlook. (2006) J. Biol. Rhythms. 21(6):507-18. DOI: 10.1177/0748730406294767

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Rudic, R.D., McNamara, P., Reilly, D., Grosser, T., Curtis, A.M., Price, T.S., Panda, S., Hogenesch, J.B., FitzGerald, G.A. Bioinformatic analysis of circadian gene oscillation in mouse aorta. (2005) Circulation. 112(17):2716-24. DOI: 10.1161/CIRCULATIONAHA.105.568626

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Panda, S., Nayak, S.K., Campo, B., Walker, J.R., Hogenesch, J.B., Jegla, T. Illumination of the melanopsin signaling pathway. (2005) Science. 307(5709):600-4. DOI: 10.1126/science.1105121

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Covington, M.F., Panda, S., Liu, X.L., Strayer, C.A., Wagner, D.R., Kay, S.A. ELF3 modulates resetting of the circadian clock in Arabidopsis. (2001) Plant Cell. 13(6):1305-15.

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Más, P., Devlin, P.F., Panda, S., Kay, S.A. Functional interaction of phytochrome B and cryptochrome 2. (2000) Nature. 408(6809):207-11. DOI: 10.1038/35041583

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Strayer, C., Oyama, T., Schultz, T.F., Raman, R., Somers, D.E., Más, P., Panda, S., Kreps, J.A., Kay, S.A. Cloning of the Arabidopsis clock gene TOC1, an autoregulatory response regulator homolog. (2000) Science. 289(5480):768-71. DOI: DOI: 10.1126/science.289.5480.768

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Harmer, S.L., Panda, S., Kay, S.A. Molecular bases of circadian rhythms. (n.d.) Annu. Rev. Cell Dev. Biol. 17:215-53. DOI: 10.1146/annurev.cellbio.17.1.215

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