Publications

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Quist, J.S., Pedersen, H.E., Jensen, M.M., Clemmensen, K.K.B., Bjerre, N., Ekblond, T.S., Uldal, S., Størling, J., Wewer Albrechtsen, N.J., Holst, J.J., Torekov, S.S., Nyeland, M.E., Vistisen, D., Jørgensen, M.E., Panda, S., Brock, C., Finlayson, G., Blond, M.B., Færch, K. Effects of 3 months of 10-h per-day time-restricted eating and 3 months of follow-up on bodyweight and cardiometabolic health in Danish individuals at high risk of type 2 diabetes: the RESET single-centre, parallel, superiority, open-label, randomised controlled trial. (2024) Lancet Healthy Longev. DOI: 10.1016/S2666-7568(24)00028-X

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Guo, Y., Abou Daya, F., Le, H.D., Panda, S., Melkani, G.C. Diurnal expression of Dgat2 induced by time-restricted feeding maintains cardiac health in the Drosophila model of circadian disruption. (2024) Aging Cell.:e14169 DOI: 10.1111/acel.14169

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Hirayama, M., Mure, L.S., Le, H.D., Panda, S. Neuronal reprogramming of mouse and human fibroblasts using transcription factors involved in suprachiasmatic nucleus development. (2024) iScience. 27(3):109051. DOI: 10.1016/j.isci.2024.109051

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van Rosmalen, L., Deota, S., Maier, G., Le, H.D., Lin, T., Ramasamy, R.K., Hut, R.A., Panda, S. Energy balance drives diurnal and nocturnal brain transcriptome rhythms. (2024) Cell Reports.:113951 DOI: 10.1016/j.celrep.2024.113951

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Zhu, X., Maier, G., Panda, S. Learning from circadian rhythm to transform cancer prevention, prognosis, and survivorship care. (2023) Trends in Cancer. DOI: 10.1016/j.trecan.2023.11.002

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Rey-Serra, C., Tituaña, J., Lin, T., Herrero, J.I., Miguel, V., Barbas, C., Meseguer, A., Ramos, R., Chaix, A., Panda, S., Lamas, S. Reciprocal regulation between the molecular clock and kidney injury. (2023) Life Sci Alliance. 6(10). DOI: 10.26508/lsa.202201886

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Panda, S. The Untapped Potential of Circadian Timing as a Variable for Discoveries and Reproducibility. (2023) Cell Mol Gastroenterol Hepatol. DOI: 10.1016/j.jcmgh.2023.06.011

Calligaro, H., Shoghi, A., Chen, X., Kim, K.Y., Yu, H.L., Khov, B., Finander, B., Le, H., Ellisman, M.H., Panda, S. Ultrastructure of synaptic connectivity within sub-regions of the suprachiasmatic nucleus revealed by a genetically encoded tag and Serial Blockface Electron Microscopy. (2023) eNeuro. DOI: 10.1523/ENEURO.0227-23.2023

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The hypothalamic suprachiasmatic nucleus (SCN) is the central circadian pacemaker in vertebrates. The SCN receives photic information exclusively through melanopsin-expressing retinal ganglion cells (mRGC) to synchronize circadian rhythms with the environmental light cycles. The SCN is composed of two major peptidergic neuron types in the core and shell regions of the SCN. Determining how mRGCs interact with the network of synaptic connections onto and between SCN neurons is key to understand how light regulates the circadian clock and to elucidate the relevant local circuits within the SCN. To map these connections, we used a newly developed Cre-dependent electron microscopy reporter, APEX2, to label the mitochondria of mRGC axons. Serial blockface scanning electron microscopy was then used to resolve the fine 3D structure of mRGC axons and synaptic boutons in the SCN of a male mouse. The resulting maps reveal patterns of connectomic organization in the core and shell of the SCN. We show that these regions are composed of different neuronal subtypes and differ with regard to the pattern of mRGC input, as the shell receives denser mRGC synaptic input compared to the core. This finding challenges the present view that photic information coming directly from the retina is received primarily by the core region of the SCN.The hypothalamic suprachiasmatic nucleus (SCN) in the vertebrate brain serves as the central pacemaker regulating circadian rhythm throughout the body and as the principal hub for entraining circadian rhythm with the ambient light:dark cycle. Cellular and molecular studies have suggested heterogeneity of the SCN neurons and their connectivity, yet an ultrastructural characterization of the SCN connectivity is still lacking. In order to systematically investigate the connectivity within the SCN, we used a recently developed Cre-dependant electron microscopy reporter, APEX2, to specifically label mitochondria of mRGCs, and SBEM to produce image volumes of the two functional sub-regions of the SCN, the core and the shell. Our findings unveil several differences between the sub-regions, including synaptic input (retinal and non-retinal), the density of network of dendrites forming dendro-dendritic synapses. In addition, we established morphological criteria for discriminating between different types of axonic boutons.

Mihaylova, M.M., Chaix, A., Delibegovic, M., Ramsey, J.J., Bass, J., Melkani, G., Singh, R., Chen, Z., Ja, W.W., Shirasu-Hiza, M., Latimer, M.N., Mattison, J.A., Thalacker-Mercer, A.E., Dixit, V.D., Panda, S., Lamming, D.W. When a calorie is not just a calorie: Diet quality and timing as mediators of metabolism and healthy aging. (2023) Cell Metabolism. DOI: 10.1016/j.cmet.2023.06.008

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Livelo, C., Guo, Y., Abou Daya, F., Rajasekaran, V., Varshney, S., Le, H.D., Barnes, S., Panda, S., Melkani, G.C. Time-restricted feeding promotes muscle function through purine cycle and AMPK signaling in Drosophila obesity models. (2023) Nature Communications. 14(1):949. DOI: 10.1038/s41467-023-36474-4

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Deota, S., Lin, T., Chaix, A., Williams, A., Le, H., Calligaro, H., Ramasamy, R., Huang, L., Panda, S. Diurnal transcriptome landscape of a multi-tissue response to time-restricted feeding in mammals. (2023) Cell Metabolism. 35(1):150-165.e4. DOI: 10.1016/j.cmet.2022.12.006

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Handzlik, M.K., Gengatharan, J.M., Frizzi, K.E., McGregor, G.H., Martino, C., Rahman, G., Gonzalez, A., Moreno, A.M., Green, C.R., Guernsey, L.S., Lin, T., Tseng, P., Ideguchi, Y., Fallon, R.J., Chaix, A., Panda, S., Mali, P., Wallace, M., Knight, R., Gantner, M.L., Calcutt, N.A., Metallo, C.M. Insulin-regulated serine and lipid metabolism drive peripheral neuropathy. (2023) Nature. DOI: 10.1038/s41586-022-05637-6

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O’Neal, M.A., Gutierrez, N.R., Laing, K.L., Manoogian, E.N.C., Panda, S. Barriers to adherence in time-restricted eating clinical trials: An early preliminary review. (2023) Front Nutr. 9:1075744. DOI: 10.3389/fnut.2022.1075744

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Lam, M.T.Y., Duttke, S.H., Odish, M.F., Le, H.D., Hansen, E.A., Nguyen, C.T., Trescott, S., Kim, R., Deota, S., Chang, M.W., Patel, A., Hepokoski, M., Alotaibi, M., Rolfsen, M., Perofsky, K., Warden, A.S., Foley, J., Ramirez, S.I., Dan, J.M., Abbott, R.K., Crotty, S., Crotty Alexander, L.E., Malhotra, A., Panda, S., Benner, C.W., Coufal, N.G. Dynamic activity in cis-regulatory elements of leukocytes identifies transcription factor activation and stratifies COVID-19 severity in ICU patients. (2023) Cell Rep Med.:100935 DOI: 10.1016/j.xcrm.2023.100935

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Bantle, A.E., Lau, K.J., Wang, Q., Malaeb, S., Harindhanavudhi, T., Manoogian, E.N.C., Panda, S., Mashek, D.G., Chow, L.S. Time-restricted eating did not alter insulin sensitivity or β-cell function in adults with obesity: A randomized pilot study. (2022) Obesity. DOI: 10.1002/oby.23620

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Dunster, G.P., Hua, I.J., Grahe, A., Fleischer, J.G., Panda, S., Wright, K.P., Vetter, C., Doherty, J.H., de la Iglesia, H.O. Daytime light exposure is a strong predictor of seasonal variation in sleep and circadian timing of university students. (2022) J Pineal Res. DOI: 10.1111/jpi.12843

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In the absence of electric light, sleep for humans typically starts soon after dusk and at higher latitudes daily sleep timing changes seasonally as photoperiod changes. However, access to electric light shields humans from natural photoperiod changes, and whether seasonal changes in sleep occur despite this isolation from the natural light-dark cycle remains a matter of controversy. We measured sleep timing in over 500 university students living in the city of Seattle, WA (47.6ºN) throughout the four seasons; we show that even when students are following a school schedule, sleep timing is delayed during the fall and winter. For instance, during the winter school days students fell asleep 35 minutes later and woke up 27 minutes later (under daylight-savings time) than students during the summer school days, a change that is an hour larger relative to solar midnight. Furthermore, chronotype defined by mid-sleep on free days corrected for oversleep (MSFc), an indirect estimate of circadian phase, was more than 30 minutes later in the winter compared to the summer. Analysis of the effect of light exposure showed that the number of hours of light exposure to at least 50 lux during the daytime was a stronger predictor of MSFc than the exposure time to this illuminance after dusk. Specifically, MSFc was advanced by 30 min for each additional hour of light exposure during daytime and delayed by only 15 min for each additional hour of post-dusk exposure to light. Additionally, the time of the day of exposure to high light intensities was more predictive of MSFc when daytime exposure was considered than when exposure for the full 24-h day was considered. Our results show that although sleep time is highly synchronized to social time, a delayed timing of sleep is evident during the winter months. They also suggest that daily exposure to daylight is key to prevent this delayed phase of the circadian clock and thus circadian disruption that is typically exacerbated in high latitude winters. This article is protected by copyright. All rights reserved.

Manoogian, E.N.C., Zadourian, A., Lo, H.C., Gutierrez, N.R., Shoghi, A., Rosander, A., Pazargadi, A., Ormiston, C.K., Wang, X., Sui, J., Hou, Z., Fleischer, J.G., Golshan, S., Taub, P.R., Panda, S. Feasibility of time-restricted eating and impacts on cardiometabolic health in 24-h shift workers: The Healthy Heroes randomized control trial. (2022) Cell Metabolism. 34(10):1442-1456.e7. DOI: 10.1016/j.cmet.2022.08.018

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Papageorgiou, M., Biver, E., Mareschal, J., Phillips, N.E., Hemmer, A., Biolley, E., Schwab, N., Manoogian, E.N.C., Gonzalez Rodriguez, E., Aeberli, D., Hans, D., Pot, C., Panda, S., Rodondi, N., Ferrari, S.L., Collet, T.H. The effects of time-restricted eating and weight loss on bone metabolism and health: a 6-month randomized controlled trial. (2022) Obesity. DOI: 10.1002/oby.23577

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Hibbing, P.R., Shook, R.P., Panda, S., Manoogian, E.N.C., Mashek, D.G., Chow, L.S. Predicting energy intake with an accelerometer-based intake-balance method. (2022) Br J Nutr.:1-23 DOI: 10.1017/S0007114522003312

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Simon, S.L., Blankenship, J., Manoogian, E.N.C., Panda, S., Mashek, D.G., Chow, L.S. The impact of a self-selected time restricted eating intervention on eating patterns, sleep, and late-night eating in individuals with obesity. (2022) Front Nutr. 9:1007824. DOI: 10.3389/fnut.2022.1007824

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Zhao, L., Hutchison, A.T., Liu, B., Wittert, G.A., Thompson, C.H., Nguyen, L., Au, J., Vincent, A., Manoogian, E.N.C., Le, H.D., Williams, A.E., Banks, S., Panda, S., Heilbronn, L.K. Time-restricted eating alters the 24-hour profile of adipose tissue transcriptome in men with obesity. (2022) Obesity. DOI: 10.1002/oby.23499

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Santos-Báez, L.S., Garbarini, A., Shaw, D., Cheng, B., Popp, C.J., Manoogian, E.N.C., Panda, S., Laferrère, B. Time-restricted eating to improve cardiometabolic health: The New York time-restricted eating randomized clinical trial – Protocol overview. (2022) Contemp Clin Trials.:106872 DOI: 10.1016/j.cct.2022.106872

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Dantas Machado, A.C., Brown, S.D., Lingaraju, A., Sivaganesh, V., Martino, C., Chaix, A., Zhao, P., Pinto, A.F.M., Chang, M.W., Richter, R.A., Saghatelian, A., Saltiel, A.R., Knight, R., Panda, S., Zarrinpar, A. Diet and feeding pattern modulate diurnal dynamics of the ileal microbiome and transcriptome. (2022) Cell Reports. 40(1):111008. DOI: 10.1016/j.celrep.2022.111008

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Deota, S., Panda, S. Aligning mealtimes to live longer. (2022) Science. 376(6598):1159-1160. DOI: 10.1126/science.adc8824

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Taub, P.R., Panda, S. Time for better time-restricted eating trials to lessen the burden of metabolic diseases. (2022) Cell Rep Med. 3(6):100665. DOI: 10.1016/j.xcrm.2022.100665

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Abbas, F., Becker, S., Jones, B.W., Mure, L.S., Panda, S., Hanneken, A., Vinberg, F. Revival of light signalling in the postmortem mouse and human retina. (2022) Nature. DOI: 10.1038/s41586-022-04709-x

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Fleischer, J.G., Das, S.K., Bhapkar, M., Manoogian, E.N.C., Panda, S. Associations between the timing of eating and weight-loss in calorically restricted healthy adults: Findings from the CALERIE study. (2022) Exp Gerontol.:111837 DOI: 10.1016/j.exger.2022.111837

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Calorie restriction (CR) and time-restricted eating (TRE) are distinctly different dietary management strategies with overlapping health outcomes. After two years of CR, healthy participants in the Comprehensive Assessment of Long-Term Effects of Reducing Intake of Energy (CALERIE) study showed significant weight-loss relative to the ad libitum intake control group and achieved 12% CR on average. Preclinical rodent studies have shown that sustaining a consistent eating interval of 8-12 h between the first and last calories of each day-without reducing daily calorie intake-can impart health benefits that partly overlap with those imparted by CR. Preclinical CR protocols often inadvertently restrict eating interval, and conversely, clinical studies of TRE often inadvertently result in modest CR. Other factors related to daily timing of food intake, such as breakfast skipping, and early food intake also impact health outcomes. These observations have raised the possibility that CR protocols can be further optimized by adopting relevant aspects of eating patterns to boost weight loss and health outcomes. With a goal to inform CR protocols that aim to optimize eating patterns, the objective of this secondary analysis was to test aspects of daily timing of food intake associated with greater weight loss in the CALERIE study participants. We found no difference in the daily time window of energy intake between the CR and control arms. In the CALERIE trial, weight change was used as a proxy for adherence to CR, and hence we used linear models to test the relationships among CR, weight loss, and temporal aspects of daily eating pattern. We found that CR alone could explain 41% of the variance in weight loss. We tested the contribution of eating interval, time to 50% daily calorie intake, and day-to-day shifts in the time of the first (breakfast) or last meal consumed. We found that eating interval and variation in the timing of the first and last meals significantly influenced weight loss after controlling for CR. Our models suggest that shorter eating intervals are associated with greater CR (1% of the variance explained) and facilitate additional weight loss. Our models suggest that less day to day variation in first mealtime is directly associated with weight loss (6% of the variance explained). More regular first meal timing is also associated with greater CR (2% of the variance explained). Likewise, regular timing of the last daily meal is directly associated with weight loss (1% of the variance explained) and greater CR (1% of the variance explained). The time to 50% of daily calorie intake or consuming half the caloric intake earlier in the day is associated with additional CR (2% of the variance explained). In summary, these secondary analyses on CALERIE data suggest that – in order to maximize CR and weight loss – future CR protocols should encourage participants to adopt consistent timing of their first and last meals, a shorter eating window, and earlier consumption of food.

Laferrère, B., Panda, S. Calorie and Time Restriction in Weight Loss. (2022) New England Journal of Medicine. 386(16):1572-1573. DOI: 10.1056/NEJMe2202821

Manoogian, E.N.C., Wei-Shatzel, J., Panda, S. Assessing temporal eating pattern in free living humans through the myCircadianClock app. (2022) International Journal of Obesity. DOI: 10.1038/s41366-021-01038-3

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Zhao, L., Hutchison, A.T., Liu, B., Yates, C.L., Teong, X.T., Wittert, G.A., Thompson, C.H., Nguyen, L., Au, J., Manoogian, E.N.C., Le, H.D., Williams, A.E., Panda, S., Banks, S., Heilbronn, L.K. Time-restricted eating improves glycemic control and dampens energy-consuming pathways in human adipose tissue. (2022) Nutrition. 96:111583. DOI: 10.1016/j.nut.2021.111583

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Calligaro, H., Dkhissi-Benyahya, O., Panda, S. Ocular and extraocular roles of neuropsin in vertebrates. (2021) Trends in Neurosciences. DOI: 10.1016/j.tins.2021.11.008

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Popp, C.J., Curran, M., Wang, C., Prasad, M., Fine, K., Gee, A., Nair, N., Perdomo, K., Chen, S., Hu, L., St-Jules, D.E., Manoogian, E.N.C., Panda, S., Sevick, M.A., Laferrère, B. Temporal Eating Patterns and Eating Windows among Adults with Overweight or Obesity. (2021) Nutrients. 13(12). DOI: 10.3390/nu13124485

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Long, H., Panda, S. Time-restricted feeding and circadian autophagy for long life. (2021) Nature Reviews Endocrinology. DOI: 10.1038/s41574-021-00600-3

Manoogian, E.N., Chow, L.S., Taub, P.R., Laferrère, B., Panda, S. Time-restricted eating for the prevention and management of metabolic diseases. (2021) Endocr Rev. DOI: 10.1210/endrev/bnab027

Zhao, L., Teong, X.T., Liu, K., Liu, B., Melaku, Y.A., Vincent, A.D., Manoogian, E.N.C., Panda, S., Wittert, G., Hutchison, A.T., Heilbronn, L.K. Eating architecture in adults at increased risk of type 2 diabetes: associations with body fat and glycaemic control. (2021) Br J Nutr.:1-28 DOI: 10.1017/S0007114521002944

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Chaix, A., Deota, S., Bhardwaj, R., Lin, T., Panda, S. Sex- and age-dependent outcomes of 9-hour time-restricted feeding of a Western high-fat high-sucrose diet in C57BL/6J mice. (2021) Cell Reports. 36(7):109543. DOI: 10.1016/j.celrep.2021.109543

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Lam, M.T.Y., Duttke, S.H., Odish, M.F., Le, H.D., Hansen, E.A., Nguyen, C.T., Trescott, S., Kim, R., Deota, S., Chang, M.W., Patel, A., Hepokoski, M., Alotaibi, M., Rolfsen, M., Perofsky, K., Warden, A.S., Foley, J., Ramirez, S.I., Dan, J.M., Abbott, R.K., Crotty, S., Crotty Alexander, L.E., Malhotra, A., Panda, S., Benner, C.W., Coufal, N.G. Profiling Transcription Initiation in Peripheral Leukocytes Reveals Severity-Associated Cis-Regulatory Elements in Critical COVID-19. (2021) bioRxiv. DOI: 10.1101/2021.08.24.457187

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Manoogian, E.N.C., Zadourian, A., Lo, H.C., Gutierrez, N.R., Shoghi, A., Rosander, A., Pazargadi, A., Wang, X., Fleischer, J.G., Golshan, S., Taub, P.R., Panda, S. Protocol for a randomised controlled trial on the feasibility and effects of 10-hour time-restricted eating on cardiometabolic disease risk among career firefighters doing 24-hour shift work: the Healthy Heroes Study. (2021) BMJ Open. 11(6):e045537. DOI: 10.1136/bmjopen-2020-045537

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Prasad, M., Fine, K., Gee, A., Nair, N., Popp, C.J., Cheng, B., Manoogian, E.N.C., Panda, S., Laferrère, B. A Smartphone Intervention to Promote Time Restricted Eating Reduces Body Weight and Blood Pressure in Adults with Overweight and Obesity: A Pilot Study. (2021) Nutrients. 13(7). DOI: 10.3390/nu13072148

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Crose, A., Alvear, A., Singroy, S., Wang, Q., Manoogian, E., Panda, S., Mashek, D.G., Chow, L.S. Time-Restricted Eating Improves Quality of Life Measures in Overweight Humans. (2021) Nutrients. 13(5). DOI: 10.3390/nu13051430

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Lobene, A.J., Panda, S., Mashek, D.G., Manoogian, E.N.C., Hill Gallant, K.M., Chow, L.S. Time-Restricted Eating for 12 Weeks Does Not Adversely Alter Bone Turnover in Overweight Adults. (2021) Nutrients. 13(4). DOI: 10.3390/nu13041155

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Phillips, N.E., Mareschal, J., Schwab, N., Manoogian, E.N.C., Borloz, S., Ostinelli, G., Gauthier-Jaques, A., Umwali, S., Rodriguez, E.G., Aeberli, D., Hans, D., Panda, S., Rodondi, N., Naef, F., Collet, T.H. The Effects of Time-Restricted Eating versus Standard Dietary Advice on Weight, Metabolic Health and the Consumption of Processed Food: A Pragmatic Randomised Controlled Trial in Community-Based Adults. (2021) Nutrients. 13(3). DOI: 10.3390/nu13031042

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Haspel, J., Kim, M., Zee, P., Schwarzmeier, T., Montagnese, S., Panda, S., Albani, A., Merrow, M. A Timely Call to Arms: COVID-19, the Circadian Clock, and Critical Care. (2021) J Biol Rhythms.:748730421992587 DOI: 10.1177/0748730421992587

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Zhou, L., Miller, C., Miraglia, L.J., Romero, A., Mure, L.S., Panda, S., Kay, S.A. A genome-wide microRNA screen identifies the microRNA-183/96/182 cluster as a modulator of circadian rhythms. (2021) Proceedings of the National Academy of Sciences of the United States of America. 118(1). DOI: 10.1073/pnas.2020454118

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Świątkiewicz, I., Mila-Kierzenkowska, C., Woźniak, A., Szewczyk-Golec, K., Nuszkiewicz, J., Wróblewska, J., Rajewski, P., Eussen, S.J.P.M., Færch, K., Manoogian, E.N.C., Panda, S., Taub, P.R. Pilot Clinical Trial of Time-Restricted Eating in Patients with Metabolic Syndrome. (2021) Nutrients. 13(2). DOI: 10.3390/nu13020346

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Malaeb, S., Harindhanavudhi, T., Dietsche, K., Esch, N., Manoogian, E.N.C., Panda, S., Mashek, D., Wang, Q., Chow, L.S. Time-Restricted Eating Alters Food Intake Patterns, as Prospectively Documented by a Smartphone Application. (2020) Nutrients. 12(11). DOI: 10.3390/nu12113396

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Deota, S., Panda, S. New Horizons: Circadian control of metabolism offers novel insight into the cause and treatment of metabolic diseases. (2020) Journal of Clinical Endocrinology and Metabolism. DOI: 10.1210/clinem/dgaa691

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Quist, J.S., Jensen, M.M., Clemmensen, K.K.B., Pedersen, H., Bjerre, N., Størling, J., Blond, M.B., Wewer Albrechtsen, N.J., Holst, J.J., Torekov, S.S., Vistisen, D., Jørgensen, M.E., Panda, S., Brock, C., Finlayson, G., Færch, K. Protocol for a single-centre, parallel-group, randomised, controlled, superiority trial on the effects of time-restricted eating on body weight, behaviour and metabolism in individuals at high risk of (2020) BMJ Open. 10(8):e037166. DOI: 10.1136/bmjopen-2020-037166

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Chow, L.S., Manoogian, E.N.C., Alvear, A., Fleischer, J.G., Thor, H., Dietsche, K., Wang, Q., Hodges, J.S., Esch, N., Malaeb, S., Harindhanavudhi, T., Nair, K.S., Panda, S., Mashek, D.G. Time-Restricted Eating Effects on Body Composition and Metabolic Measures in Humans with Overweight: A Feasibility Study. (2020) Obesity. DOI: 10.1002/oby.22756

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Mure, L.S., Vinberg, F., Hanneken, A., Panda, S. Functional diversity of human intrinsically photosensitive retinal ganglion cells. (2019) Science. 366(6470):1251-1255. DOI: 10.1126/science.aaz0898

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Wilkinson, M.J., Manoogian, E.N.C., Zadourian, A., Lo, H., Fakhouri, S., Shoghi, A., Wang, X., Fleischer, J.G., Navlakha, S., Panda, S., Taub, P.R. Ten-Hour Time-Restricted Eating Reduces Weight, Blood Pressure, and Atherogenic Lipids in Patients with Metabolic Syndrome. (2019) Cell Metabolism. 31(1):92-104. DOI: 10.1016/j.cmet.2019.11.004

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Manoogian, E.N.C., Chaix, A., Panda, S. When to Eat: The Importance of Eating Patterns in Health and Disease. (2019) Journal of Biological Rhythms. 34(6):579-581. DOI: 10.1177/0748730419892105

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Kim, K.Y., Rios, L.C., Le, H., Perez, A.J., Phan, S., Bushong, E.A., Deerinck, T.J., Liu, Y.H., Ellisman, M.A., Lev-Ram, V., Ju, S., Panda, S.A., Yoon, S., Hirayama, M., Mure, L.S., Hatori, M., Ellisman, M.H., Panda, S. Synaptic Specializations of Melanopsin-Retinal Ganglion Cells in Multiple Brain Regions Revealed by Genetic Label for Light and Electron Microscopy. (2019) Cell Reports. 29(3):628-644.e6. DOI: 10.1016/j.celrep.2019.09.006

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Faerch, K., Quist, J.S., Hulman, A., Witte, D.R., Tabak, A.G., Brunner, E.J., Kivimäki, M., Jørgensen, M.E., Panda, S., Vistisen, D. Prospective association between late evening food consumption and risk of prediabetes and diabetes: the Whitehall II cohort study. (2019) Diabet Med. 36(10):1256-1260. DOI: 10.1111/dme.13951

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Heilbronn, L.K., Panda, S. Alternate-Day Fasting Gets a Safe Bill of Health. (2019) Cell Metabolism. 30(3):411-413. DOI: 10.1016/j.cmet.2019.08.006

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Sulli, G., Lam, M.T.Y., Panda, S. Interplay between Circadian Clock and Cancer: New Frontiers for Cancer Treatment. (2019) Trends in Cancer. 5(8):475-494. DOI: 10.1016/j.trecan.2019.07.002

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Chaix, A., Manoogian, E.N.C., Melkani, G.C., Panda, S. Time-Restricted Eating to Prevent and Manage Chronic Metabolic Diseases. (2019) Annu. Rev. Nutr. 39:291-315. DOI: 10.1146/annurev-nutr-082018-124320

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Chaix, A., Panda, S. Timing tweaks exercise. (2019) Nature Reviews Endocrinology. 15(8):440-441. DOI: 10.1038/s41574-019-0229-z

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Villanueva, J.E., Livelo, C., Trujillo, A.S., Chandran, S., Woodworth, B., Andrade, L., Le, H.D., Manor, U., Panda, S., Melkani, G.C. Time-restricted feeding restores muscle function in Drosophila models of obesity and circadian-rhythm disruption. (2019) Nature Communications. 10(1):2700. DOI: 10.1038/s41467-019-10563-9

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Hutchison, A.T., Regmi, P., Manoogian, E.N.C., Fleischer, J.G., Wittert, G.A., Panda, S., Heilbronn, L.K. Time-Restricted Feeding Improves Glucose Tolerance in Men at Risk for Type 2 Diabetes: A Randomized Crossover Trial. (2019) Obesity. 27(5):724–732. DOI: 10.1002/oby.22449

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Panda, S. The arrival of circadian medicine. (2019) Nature Reviews Endocrinology. DOI: 10.1038/s41574-018-0142-x

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Garcia, D., Hellberg, K., Chaix, A., Wallace, M., Herzig, S., Badur, M.G., Lin, T., Shokhirev, M.N., Pinto, A.F.M., Ross, D.S., Saghatelian, A., Panda, S., Dow, L.E., Metallo, C.M., Shaw, R.J. Genetic Liver-Specific AMPK Activation Protects against Diet-Induced Obesity and NAFLD. (2019) Cell Reports. 26(1):192-208.e6. DOI: 10.1016/j.celrep.2018.12.036

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Dunster, G.P., de la Iglesia, L., Ben-Hamo, M., Nave, C., Fleischer, J.G., Panda, S., de la Iglesia, H.O. Sleepmore in Seattle: Later school start times are associated with more sleep and better performance in high school students. (2018) Science Advances. 4(12):eaau6200. DOI: 10.1126/sciadv.aau6200

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Mure, L.S., Hatori, M., Ruda, K., Benegiamo, G., Demas, J., Panda, S. Sustained Melanopsin Photoresponse Is Supported by Specific Roles of β-Arrestin 1 and 2 in Deactivation and Regeneration of Photopigment. (2018) Cell Reports. 25(9):2497-2509.e4. DOI: 10.1016/j.celrep.2018.11.008

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Chaix, A., Lin, T., Le, H.D., Chang, M.W., Panda, S. Time-Restricted Feeding Prevents Obesity and Metabolic Syndrome in Mice Lacking a Circadian Clock. (2018) Cell Metabolism. 29(2):303–319. DOI: 10.1016/j.cmet.2018.08.004

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Zarrinpar, A., Chaix, A., Xu, Z.Z., Chang, M.W., Marotz, C.A., Saghatelian, A., Knight, R., Panda, S. Antibiotic-induced microbiome depletion alters metabolic homeostasis by affecting gut signaling and colonic metabolism. (2018) Nature Communications. 9(1):2872. DOI: 10.1038/s41467-018-05336-9

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Sulli, G., Manoogian, E.N.C., Taub, P.R., Panda, S. Training the Circadian Clock, Clocking the Drugs, and Drugging the Clock to Prevent, Manage, and Treat Chronic Diseases. (2018) Trends in Pharmacological Sciences. 39(9):812–827. DOI: 10.1016/j.tips.2018.07.003

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Gabel, K., Hoddy, K.K., Haggerty, N., Song, J., Kroeger, C.M., Trepanowski, J.F., Panda, S., Varady, K.A. Effects of 8-hour time restricted feeding on body weight and metabolic disease risk factors in obese adults: A pilot study. (2018) Nutr Healthy Aging. 4(4):345-353. DOI: 10.3233/NHA-170036

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Mure, L.S., Le, H.D., Benegiamo, G., Chang, M.W., Rios, L., Jillani, N., Ngotho, M., Kariuki, T., Dkhissi-Benyahya, O., Cooper, H.M., Panda, S. Diurnal transcriptome atlas of a primate across major neural and peripheral tissues. (2018) Science. 359(6381). DOI: 10.1126/science.aao0318

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Sulli, G., Rommel, A., Wang, X., Kolar, M.J., Puca, F., Saghatelian, A., Plikus, M.V., Verma, I.M., Panda, S. Pharmacological activation of REV-ERBs is lethal in cancer and oncogene-induced senescence. (2018) Nature. 553(7688):351-355. DOI: 10.1038/nature25170

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Benegiamo, G., Mure, L.S., Erikson, G., Le, H.D., Moriggi, E., Brown, S.A., Panda, S. The RNA-Binding Protein NONO Coordinates Hepatic Adaptation to Feeding. (2018) Cell Metabolism. 27(2):404-418. DOI: 10.1016/j.cmet.2017.12.010

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Lunn, R.M., Blask, D.E., Coogan, A.N., Figueiro, M.G., Gorman, M.R., Hall, J.E., Hansen, J., Nelson, R.J., Panda, S., Smolensky, M.H., Stevens, R.G., Turek, F.W., Vermeulen, R., Carreón, T., Caruso, C.C., Lawson, C.C., Thayer, K.A., Twery, M.J., Ewens, A.D., Garner, S.C., Schwingl, P.J., Boyd, W.A. Health consequences of electric lighting practices in the modern world: A report on the National Toxicology Program’s workshop on shift work at night, artificial light at night, and circadian disrupti (2017) Science of the Total Environment. 607-608:1073-1084. DOI: 10.1016/j.scitotenv.2017.07.056

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Manoogian, E.N.C., Panda, S. Circadian rhythms, time-restricted feeding, and healthy aging. (2017) Ageing Research Reviews. 39:59-67. DOI: 10.1016/j.arr.2016.12.006

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Hatori, M., Gronfier, C., Van Gelder, R.N., Bernstein, P.S., Carreras, J., Panda, S., Marks, F., Sliney, D., Hunt, C.E., Hirota, T., Furukawa, T., Tsubota, K. Global rise of potential health hazards caused by blue light-induced circadian disruption in modern aging societies. (2017) NPJ Aging and Mechanisms of Disease. 3:9. DOI: 10.1038/s41514-017-0010-2

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Melkani, G.C., Panda, S. Time-restricted feeding for prevention and treatment of cardiometabolic disorders. (2017) Journal of Physiology. 595(12):3691-3700. DOI: 10.1113/JP273094

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Gupta, N.J., Kumar, V., Panda, S. A camera-phone based study reveals erratic eating pattern and disrupted daily eating-fasting cycle among adults in India. (2017) PLOS One. 12(3):e0172852. DOI: 10.1371/journal.pone.0172852

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The daily rhythm of feeding-fasting and meal-timing are emerging as important determinants of health. Circadian rhythm research in animal models and retrospective analyses of human nutrition data have shown that reduced length of overnight fasting or increased late night eating increases risk for metabolic diseases including obesity and diabetes. However, the daily rhythm in eating pattern in humans is rarely measured. Traditional methods to collect nutrition information through food diary and food log pay little attention to the timing of eating which may also change from day to day. We adopted a novel cell-phone based approach to longitudinally record all events of food and beverage intake in adults. In a feasibility study daily food-eating patterns of 93 healthy individuals were recorded for 21 days using camera phones. Analysis of the daily eating patterns of these individuals indicates deviation from conventional assumption that people eat three meals-a-day within a 12 h interval. We found that eating events are widespread throughout the day, with <30% of calories consumed before noon and >30% consumed in evening and late night hours. There was little difference in eating pattern between weekdays and weekends. In this cohort more than 50% of people spread their caloric intake events over 15 h or longer. One decile of the cohort who were spouses of shift-workers or had flexible work schedule spread their caloric intake over 20 h. Although the nutrition quality and diversity of food consumed is different between South-East Asian and Western countries, such overall disruption of daily eating-fasting rhythm is similar. Therefore, in view of hypothesis that disrupted daily eating pattern may contribute to the global increase in metabolic diseases and modification of daily eating pattern is a potential modifiable behavior to contain these diseases, monitoring eating pattern is an important aspect of lifestyle.

Kofuji, P., Mure, L.S., Massman, L.J., Purrier, N., Panda, S., Engeland, W.C. Intrinsically Photosensitive Retinal Ganglion Cells (ipRGCs) Are Necessary for Light Entrainment of Peripheral Clocks. (2016) PLOS One. 11(12):e0168651. DOI: 10.1371/journal.pone.0168651

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Light is a powerful entrainer of circadian clocks in almost all eukaryotic organisms promoting synchronization of internal circadian rhythms with external environmental light-dark (LD) cycles. In mammals, the circadian system is organized in a hierarchical manner, in which a central pacemaker in the suprachiasmatic nucleus (SCN) synchronizes oscillators in peripheral tissues. Recent evidence demonstrates that photoentrainment of the SCN proceeds via signaling from a subpopulation of retinal ganglion cells (RGCs) which are melanopsin-expressing and intrinsically photosensitive (ipRGCs). However, it is still unclear whether photoentrainment of peripheral clocks is mediated exclusively by the ipRGC system or if signaling from RGCs that do not express melanopsin also plays a role. Here we have used genetic “silencing” of ipRGC neurotransmission in mice to investigate whether this photoreceptive system is obligatory for the photoentrainment of peripheral circadian clocks. Genetic silencing of ipRGC neurotransmission in mice was achieved by expression of tetanus toxin light chain in melanopsin-expressing cells (Opn4::TeNT mouse line). Rhythms of the clock gene Period 2 in various peripheral tissues were measured by crossbreeding Opn4::TeNT mice with PER2 luciferase knock-in mice (mPER2Luc). We found that in Opn4::TeNT mice the pupillary light reflex, light modulation of activity, and circadian photoentrainment of locomotor activity were severely impaired. Furthermore, ex vivo cultures from Opn4::TeNT, mPER2Luc mice of the adrenal gland, cornea, lung, liver, pituitary and spleen exhibited robust circadian rhythms of PER2::LUC bioluminescence. However, their peak bioluminescence rhythms were not aligned to the projected LD cycles indicating their lack of photic entrainment in vivo. Finally, we found that the circadian rhythm in adrenal corticosterone in Opn4::TeNT mice, as monitored by in vivo subcutaneous microdialysis, was desynchronized from environmental LD cycles. Our findings reveal a non-redundant role of ipRGCs for photic entrainment of peripheral tissues, highlighting the importance of this photoreceptive system for the organismal adaptation to daily environmental LD cycles.

Panda, S. Circadian physiology of metabolism. (2016) Science. 354(6315):1008-1015. DOI: 10.1126/science.aah4967

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Chaix, A., Zarrinpar, A., Panda, S. The circadian coordination of cell biology. (2016) Journal of Cell Biology. 215(1):15-25. DOI: 10.1083/jcb.201603076

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Longo, V.D., Panda, S. Fasting, Circadian Rhythms, and Time-Restricted Feeding in Healthy Lifespan. (2016) Cell Metabolism. 23(6):1048-1059. DOI: 10.1016/j.cmet.2016.06.001

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Mure, L.S., Hatori, M., Zhu, Q., Demas, J., Kim, I.M., Nayak, S.K., Panda, S. Melanopsin-Encoded Response Properties of Intrinsically Photosensitive Retinal Ganglion Cells. (2016) Neuron. 90(5):1016-27. DOI: 10.1016/j.neuron.2016.04.016

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Chaix, A., Panda, S. Ketone Bodies Signal Opportunistic Food-Seeking Activity. (2016) Trends in Endocrinology and Metabolism. 27(6):350-2. DOI: 10.1016/j.tem.2016.03.014

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Manoogian, E.N., Panda, S. Circadian clock, nutrient quality, and eating pattern tune diurnal rhythms in the mitochondrial proteome. (2016) Proceedings of the National Academy of Sciences of the United States of America. 113(12):3127-9. DOI: 10.1073/pnas.1601786113

Zarrinpar, A., Chaix, A., Panda, S. Daily Eating Patterns and Their Impact on Health and Disease. (2016) Trends in Endocrinology and Metabolism. 27(2):69-83. DOI: 10.1016/j.tem.2015.11.007

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Benegiamo, G., Brown, S.A., Panda, S. RNA Dynamics in the Control of Circadian Rhythm. (2016) Advances in Experimental Medicine and Biology. 907:107-22. DOI: 10.1007/978-3-319-29073-7_5

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Arble, D.M., Bass, J., Behn, C.D., Butler, M.P., Challet, E., Czeisler, C., Depner, C.M., Elmquist, J., Franken, P., Grandner, M.A., Hanlon, E.C., Keene, A.C., Joyner, M.J., Karatsoreos, I., Kern, P.A., Klein, S., Morris, C.J., Pack, A.I., Panda, S., Ptacek, L.J., Punjabi, N.M., Sassone-Corsi, P., Scheer, F.A., Saxena, R., Seaquest, E.R., Thimgan, M.S., Van Cauter, E., Wright, K.P. Impact of Sleep and Circadian Disruption on Energy Balance and Diabetes: A Summary of Workshop Discussions. (2015) Sleep. 38(12):1849-60. DOI: 10.5665/sleep.5226

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Gill, S., Panda, S. A Smartphone App Reveals Erratic Diurnal Eating Patterns in Humans that Can Be Modulated for Health Benefits. (2015) Cell Metabolism. 22(5):789-98. DOI: 10.1016/j.cmet.2015.09.005

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Singh, D., Trivedi, A.K., Rani, S., Panda, S., Kumar, V. Circadian timing in central and peripheral tissues in a migratory songbird: dependence on annual life-history states. (2015) FASEB Journal. 29(10):4248-55. DOI: 10.1096/fj.15-275339

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Gill, S., Le, H.D., Melkani, G.C., Panda, S. Time-restricted feeding attenuates age-related cardiac decline in Drosophila. (2015) Science. 347(6227):1265-9. DOI: 10.1126/science.1256682

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Bushong, E.A., Johnson, D.D., Kim, K.Y., Terada, M., Hatori, M., Peltier, S.T., Panda, S., Merkle, A., Ellisman, M.H. X-ray microscopy as an approach to increasing accuracy and efficiency of serial block-face imaging for correlated light and electron microscopy of biological specimens. (2015) Microsc. Microanal. 21(1):231-8. DOI: 10.1017/S1431927614013579

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Hatori, M., Panda, S. Response of peripheral rhythms to the timing of food intake. (2015) Meth. Enzymol. 552:145-61. DOI: 10.1016/bs.mie.2014.10.027

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Zarrinpar, A., Chaix, A., Yooseph, S., Panda, S. Diet and feeding pattern affect the diurnal dynamics of the gut microbiome. (2014) Cell Metabolism. 20(6):1006-17. DOI: 10.1016/j.cmet.2014.11.008

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Chaix, A., Zarrinpar, A., Miu, P., Panda, S. Time-restricted feeding is a preventative and therapeutic intervention against diverse nutritional challenges. (2014) Cell Metabolism. 20(6):991-1005. DOI: 10.1016/j.cmet.2014.11.001

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Perez, A.J., Seyedhosseini, M., Deerinck, T.J., Bushong, E.A., Panda, S., Tasdizen, T., Ellisman, M.H. A workflow for the automatic segmentation of organelles in electron microscopy image stacks. (2014) Frontiers in Neuroanatomy. 8:126. DOI: 10.3389/fnana.2014.00126

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Mattson, M.P., Allison, D.B., Fontana, L., Harvie, M., Longo, V.D., Malaisse, W.J., Mosley, M., Notterpek, L., Ravussin, E., Scheer, F.A., Seyfried, T.N., Varady, K.A., Panda, S. Meal frequency and timing in health and disease. (2014) Proceedings of the National Academy of Sciences of the United States of America. 111(47):16647-53. DOI: 10.1073/pnas.1413965111

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Pieraut, S., Gounko, N., Sando, R., Dang, W., Rebboah, E., Panda, S., Madisen, L., Zeng, H., Maximov, A. Experience-dependent remodeling of basket cell networks in the dentate gyrus. (2014) Neuron. 84(1):107-22. DOI: 10.1016/j.neuron.2014.09.012

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Mao, C.A., Li, H., Zhang, Z., Kiyama, T., Panda, S., Hattar, S., Ribelayga, C.P., Mills, S.L., Wang, S.W. T-box transcription regulator Tbr2 is essential for the formation and maintenance of Opn4/melanopsin-expressing intrinsically photosensitive retinal ganglion cells. (2014) Journal of Neuroscience. 34(39):13083-95. DOI: 10.1523/JNEUROSCI.1027-14.2014

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Hatori, M., Gill, S., Mure, L.S., Goulding, M., O’Leary, D.D., Panda, S. Lhx1 maintains synchrony among circadian oscillator neurons of the SCN. (2014) Elife. 3:e03357. DOI: 10.7554/eLife.03357

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Liu, Z., Huang, M., Wu, X., Shi, G., Xing, L., Dong, Z., Qu, Z., Yan, J., Yang, L., Panda, S., Xu, Y. PER1 phosphorylation specifies feeding rhythm in mice. (2014) Cell Reports. 7(5):1509-20. DOI: 10.1016/j.celrep.2014.04.032

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Hatori, M., Panda, S. Nucleosome dynamics regulate Neurospora circadian clock. (2013) EMBO Reports. 14(10):854-5. DOI: 10.1038/embor.2013.143

Jones, K.A., Hatori, M., Mure, L.S., Bramley, J.R., Artymyshyn, R., Hong, S.P., Marzabadi, M., Zhong, H., Sprouse, J., Zhu, Q., Hartwick, A.T., Sollars, P.J., Pickard, G.E., Panda, S. Small-molecule antagonists of melanopsin-mediated phototransduction. (2013) Nature Chemical Biology. 9(10):630-5. DOI: 10.1038/nchembio.1333

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Hardin, P.E., Panda, S. Circadian timekeeping and output mechanisms in animals. (2013) Current Opinion in Neurobiology. 23(5):724-31. DOI: 10.1016/j.conb.2013.02.018

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Fischer, R.M., Fontinha, B.M., Kirchmaier, S., Steger, J., Bloch, S., Inoue, D., Panda, S., Rumpel, S., Tessmar-Raible, K. Co-expression of VAL- and TMT-opsins uncovers ancient photosensory interneurons and motorneurons in the vertebrate brain. (2013) PLOS Biology. 11(6):e1001585. DOI: 10.1371/journal.pbio.1001585

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The functional principle of the vertebrate brain is often paralleled to a computer: information collected by dedicated devices is processed and integrated by interneuron circuits and leads to output. However, inter- and motorneurons present in today’s vertebrate brains are thought to derive from neurons that combined sensory, integration, and motor function. Consistently, sensory inter-motorneurons have been found in the simple nerve nets of cnidarians, animals at the base of the evolutionary lineage. We show that light-sensory motorneurons and light-sensory interneurons are also present in the brains of vertebrates, challenging the paradigm that information processing and output circuitry in the central brain is shielded from direct environmental influences. We investigated two groups of nonvisual photopigments, VAL- and TMT-Opsins, in zebrafish and medaka fish; two teleost species from distinct habitats separated by over 300 million years of evolution. TMT-Opsin subclasses are specifically expressed not only in hypothalamic and thalamic deep brain photoreceptors, but also in interneurons and motorneurons with no known photoreceptive function, such as the typeXIV interneurons of the fish optic tectum. We further show that TMT-Opsins and Encephalopsin render neuronal cells light-sensitive. TMT-Opsins preferentially respond to blue light relative to rhodopsin, with subclass-specific response kinetics. We discovered that tmt-opsins co-express with val-opsins, known green light receptors, in distinct inter- and motorneurons. Finally, we show by electrophysiological recordings on isolated adult tectal slices that interneurons in the position of typeXIV neurons respond to light. Our work supports “sensory-inter-motorneurons” as ancient units for brain evolution. It also reveals that vertebrate inter- and motorneurons are endowed with an evolutionarily ancient, complex light-sensory ability that could be used to detect changes in ambient light spectra, possibly providing the endogenous equivalent to an optogenetic machinery.

Plikus, M.V., Vollmers, C., de la Cruz, D., Chaix, A., Ramos, R., Panda, S., Chuong, C.M. Local circadian clock gates cell cycle progression of transient amplifying cells during regenerative hair cycling. (2013) Proceedings of the National Academy of Sciences of the United States of America. 110(23):E2106-15. DOI: 10.1073/pnas.1215935110

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Clark, D.D., Gorman, M.R., Hatori, M., Meadows, J.D., Panda, S., Mellon, P.L. Aberrant development of the suprachiasmatic nucleus and circadian rhythms in mice lacking the homeodomain protein Six6. (2013) J. Biol. Rhythms. 28(1):15-25. DOI: 10.1177/0748730412468084

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Vollmers, C., Schmitz, R.J., Nathanson, J., Yeo, G., Ecker, J.R., Panda, S. Circadian oscillations of protein-coding and regulatory RNAs in a highly dynamic mammalian liver epigenome. (2012) Cell Metabolism. 16(6):833-45. DOI: 10.1016/j.cmet.2012.11.004

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Mure, L.S., Panda, S. Fear of the light or need for action: the IGL will judge. (2012) Neuron. 75(4):546-8. DOI: 10.1016/j.neuron.2012.08.012

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Narasimamurthy, R., Hatori, M., Nayak, S.K., Liu, F., Panda, S., Verma, I.M. Circadian clock protein cryptochrome regulates the expression of proinflammatory cytokines. (2012) Proceedings of the National Academy of Sciences of the United States of America. 109(31):12662-7. DOI: 10.1073/pnas.1209965109

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Hatori, M., Vollmers, C., Zarrinpar, A., DiTacchio, L., Bushong, E.A., Gill, S., Leblanc, M., Chaix, A., Joens, M., Fitzpatrick, J.A., Ellisman, M.H., Panda, S. Time-restricted feeding without reducing caloric intake prevents metabolic diseases in mice fed a high-fat diet. (2012) Cell Metabolism. 15(6):848-60. DOI: 10.1016/j.cmet.2012.04.019

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Cho, H., Zhao, X., Hatori, M., Yu, R.T., Barish, G.D., Lam, M.T., Chong, L.W., DiTacchio, L., Atkins, A.R., Glass, C.K., Liddle, C., Auwerx, J., Downes, M., Panda, S., Evans, R.M. Regulation of circadian behaviour and metabolism by REV-ERB-α and REV-ERB-β. (2012) Nature. 485(7396):123-7. DOI: 10.1038/nature11048

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Siegert, S., Cabuy, E., Scherf, B.G., Kohler, H., Panda, S., Le, Y.Z., Fehling, H.J., Gaidatzis, D., Stadler, M.B., Roska, B. Transcriptional code and disease map for adult retinal cell types. (2012) Nature Neuroscience. 15(3):487-95, S1-2. DOI: 10.1038/nn.3032

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Xu, J., Cohen, B.N., Zhu, Y., Dziewczapolski, G., Panda, S., Lester, H.A., Heinemann, S.F., Contractor, A. Altered activity-rest patterns in mice with a human autosomal-dominant nocturnal frontal lobe epilepsy mutation in the β2 nicotinic receptor. (2011) Molecular Psychiatry. 16(10):1048-61. DOI: 10.1038/mp.2010.78

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DiTacchio, L., Le, H.D., Vollmers, C., Hatori, M., Witcher, M., Secombe, J., Panda, S. Histone lysine demethylase JARID1a activates CLOCK-BMAL1 and influences the circadian clock. (2011) Science. 333(6051):1881-5. DOI: 10.1126/science.1206022

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Ma, D., Panda, S., Lin, J.D. Temporal orchestration of circadian autophagy rhythm by C/EBPβ. (2011) EMBO Journal. 30(22):4642-51. DOI: 10.1038/emboj.2011.322

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Park, D., Hadžić, T., Yin, P., Rusch, J., Abruzzi, K., Rosbash, M., Skeath, J.B., Panda, S., Sweedler, J.V., Taghert, P.H. Molecular organization of Drosophila neuroendocrine cells by Dimmed. (2011) Current Biology. 21(18):1515-24. DOI: 10.1016/j.cub.2011.08.015

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Gill, S., Panda, S. Feeding mistiming decreases reproductive fitness in flies. (2011) Cell Metabolism. 13(6):613-4. DOI: 10.1016/j.cmet.2011.05.003

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Hatori, M., Panda, S. CRY links the circadian clock and CREB-mediated gluconeogenesis. (2010) Cell Research. 20(12):1285-8. DOI: 10.1038/cr.2010.152

Brown, T.M., Gias, C., Hatori, M., Keding, S.R., Semo, M., Coffey, P.J., Gigg, J., Piggins, H.D., Panda, S., Lucas, R.J. Melanopsin contributions to irradiance coding in the thalamo-cortical visual system. (2010) PLOS Biology. 8(12):e1000558. DOI: 10.1371/journal.pbio.1000558

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Jones, M.A., Covington, M.F., DiTacchio, L., Vollmers, C., Panda, S., Harmer, S.L. Jumonji domain protein JMJD5 functions in both the plant and human circadian systems. (2010) Proceedings of the National Academy of Sciences of the United States of America. 107(50):21623-8. DOI: 10.1073/pnas.1014204108

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Hatori, M., Panda, S. The emerging roles of melanopsin in behavioral adaptation to light. (2010) Trends in Molecular Medicine. 16(10):435-46. DOI: 10.1016/j.molmed.2010.07.005

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Vollmers, C., Gill, S., DiTacchio, L., Pulivarthy, S.R., Le, H.D., Panda, S. Time of feeding and the intrinsic circadian clock drive rhythms in hepatic gene expression. (2009) Proceedings of the National Academy of Sciences of the United States of America. 106(50):21453-8. DOI: 10.1073/pnas.0909591106

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Lamia, K.A., Sachdeva, U.M., DiTacchio, L., Williams, E.C., Alvarez, J.G., Egan, D.F., Vasquez, D.S., Juguilon, H., Panda, S., Shaw, R.J., Thompson, C.B., Evans, R.M. AMPK regulates the circadian clock by cryptochrome phosphorylation and degradation. (2009) Science. 326(5951):437-40. DOI: 10.1126/science.1172156

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Hitomi, K., DiTacchio, L., Arvai, A.S., Yamamoto, J., Kim, S.T., Todo, T., Tainer, J.A., Iwai, S., Panda, S., Getzoff, E.D. Functional motifs in the (6-4) photolyase crystal structure make a comparative framework for DNA repair photolyases and clock cryptochromes. (2009) Proceedings of the National Academy of Sciences of the United States of America. 106(17):6962-7. DOI: 10.1073/pnas.0809180106

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Hughes, M.E., DiTacchio, L., Hayes, K.R., Vollmers, C., Pulivarthy, S., Baggs, J.E., Panda, S., Hogenesch, J.B. Harmonics of circadian gene transcription in mammals. (2009) PLOS Genetics. 5(4):e1000442. DOI: 10.1371/journal.pgen.1000442

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Baggs, J.E., Price, T.S., DiTacchio, L., Panda, S., Fitzgerald, G.A., Hogenesch, J.B. Network features of the mammalian circadian clock. (2009) PLOS Biology. 7(3):e52. DOI: 10.1371/journal.pbio.1000052

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Vollmers, C., Panda, S., DiTacchio, L. A high-throughput assay for siRNA-based circadian screens in human U2OS cells. (2008) PLOS One. 3(10):e3457. DOI: 10.1371/journal.pone.0003457

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Lin, B., Koizumi, A., Tanaka, N., Panda, S., Masland, R.H. Restoration of visual function in retinal degeneration mice by ectopic expression of melanopsin. (2008) Proceedings of the National Academy of Sciences of the United States of America. 105(41):16009-14. DOI: 10.1073/pnas.0806114105

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Hatori, M., Le, H., Vollmers, C., Keding, S.R., Tanaka, N., Buch, T., Waisman, A., Schmedt, C., Jegla, T., Panda, S. Inducible ablation of melanopsin-expressing retinal ganglion cells reveals their central role in non-image forming visual responses. (2008) PLOS One. 3(6):e2451. DOI: 10.1371/journal.pone.0002451

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Pulivarthy, S.R., Tanaka, N., Welsh, D.K., De Haro, L., Verma, I.M., Panda, S. Reciprocity between phase shifts and amplitude changes in the mammalian circadian clock. (2007) Proceedings of the National Academy of Sciences of the United States of America. 104(51):20356-61. DOI: 10.1073/pnas.0708877104

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Kozlov, S.V., Bogenpohl, J.W., Howell, M.P., Wevrick, R., Panda, S., Hogenesch, J.B., Muglia, L.J., Van Gelder, R.N., Herzog, E.D., Stewart, C.L. The imprinted gene Magel2 regulates normal circadian output. (2007) Nature Genetics. 39(10):1266-72. DOI: 10.1038/ng2114

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Hughes, M., Deharo, L., Pulivarthy, S.R., Gu, J., Hayes, K., Panda, S., Hogenesch, J.B. High-resolution time course analysis of gene expression from pituitary. (2007) Cold Spring Harbor Symposia on Quantitative Biology. 72:381-6. DOI: 10.1101/sqb.2007.72.011

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Panda, S. Multiple photopigments entrain the Mammalian circadian oscillator. (2007) Neuron. 53(5):619-21. DOI: 10.1016/j.neuron.2007.02.017

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Miller, B.H., McDearmon, E.L., Panda, S., Hayes, K.R., Zhang, J., Andrews, J.L., Antoch, M.P., Walker, J.R., Esser, K.A., Hogenesch, J.B., Takahashi, J.S. Circadian and CLOCK-controlled regulation of the mouse transcriptome and cell proliferation. (2007) Proceedings of the National Academy of Sciences of the United States of America. 104(9):3342-7. DOI: 10.1073/pnas.0611724104

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Nayak, S.K., Jegla, T., Panda, S. Role of a novel photopigment, melanopsin, in behavioral adaptation to light. (2007) Cellular and Molecular Life Sciences. 64(2):144-54. DOI: 10.1007/s00018-006-5581-1

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De Haro, L., Panda, S. Systems biology of circadian rhythms: an outlook. (2006) J. Biol. Rhythms. 21(6):507-18. DOI: 10.1177/0748730406294767

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Rudic, R.D., McNamara, P., Reilly, D., Grosser, T., Curtis, A.M., Price, T.S., Panda, S., Hogenesch, J.B., FitzGerald, G.A. Bioinformatic analysis of circadian gene oscillation in mouse aorta. (2005) Circulation. 112(17):2716-24. DOI: 10.1161/CIRCULATIONAHA.105.568626

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Panda, S., Nayak, S.K., Campo, B., Walker, J.R., Hogenesch, J.B., Jegla, T. Illumination of the melanopsin signaling pathway. (2005) Science. 307(5709):600-4. DOI: 10.1126/science.1105121

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Rudic, R.D., McNamara, P., Curtis, A.M., Boston, R.C., Panda, S., Hogenesch, J.B., Fitzgerald, G.A. BMAL1 and CLOCK, two essential components of the circadian clock, are involved in glucose homeostasis. (2004) PLOS Biology. 2(11):e377. DOI: 10.1371/journal.pbio.0020377

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Panda, S., Hogenesch, J.B. It’s all in the timing: many clocks, many outputs. (2004) J. Biol. Rhythms. 19(5):374-87. DOI: 10.1177/0748730404269008

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Sato, T.K., Panda, S., Miraglia, L.J., Reyes, T.M., Rudic, R.D., McNamara, P., Naik, K.A., FitzGerald, G.A., Kay, S.A., Hogenesch, J.B. A functional genomics strategy reveals Rora as a component of the mammalian circadian clock. (2004) Neuron. 43(4):527-37. DOI: 10.1016/j.neuron.2004.07.018

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Grechez-Cassiau, A., Panda, S., Lacoche, S., Teboul, M., Azmi, S., Laudet, V., Hogenesch, J.B., Taneja, R., Delaunay, F. The transcriptional repressor STRA13 regulates a subset of peripheral circadian outputs. (2004) Journal of Biological Chemistry. 279(2):1141-50. DOI: 10.1074/jbc.M305369200

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Panda, S., Provencio, I., Tu, D.C., Pires, S.S., Rollag, M.D., Castrucci, A.M., Pletcher, M.T., Sato, T.K., Wiltshire, T., Andahazy, M., Kay, S.A., Van Gelder, R.N., Hogenesch, J.B. Melanopsin is required for non-image-forming photic responses in blind mice. (2003) Science. 301(5632):525-7. DOI: 10.1126/science.1086179

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Sato, T.K., Panda, S., Kay, S.A., Hogenesch, J.B. DNA arrays: applications and implications for circadian biology. (2003) J. Biol. Rhythms. 18(2):96-105. DOI: 10.1177/0748730403252245

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Panda, S., Sato, T.K., Hampton, G.M., Hogenesch, J.B. An array of insights: application of DNA chip technology in the study of cell biology. (2003) Trends in Cell Biology. 13(3):151-6.

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Hogenesch, J.B., Panda, S., Kay, S., Takahashi, J.S. Circadian transcriptional output in the SCN and liver of the mouse. (2003) Novartis Found. Symp. 253:171-80; discussion 52-5, 102-9.

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Panda, S., Hogenesch, J.B., Kay, S.A. Circadian light input in plants, flies and mammals. (2003) Novartis Found. Symp. 253:73-82; discussion 82-8, 102-9,.

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Panda, S., Sato, T.K., Castrucci, A.M., Rollag, M.D., DeGrip, W.J., Hogenesch, J.B., Provencio, I., Kay, S.A. Melanopsin (Opn4) requirement for normal light-induced circadian phase shifting. (2002) Science. 298(5601):2213-6. DOI: 10.1126/science.1076848

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Ceriani, M.F., Hogenesch, J.B., Yanovsky, M., Panda, S., Straume, M., Kay, S.A. Genome-wide expression analysis in Drosophila reveals genes controlling circadian behavior. (2002) Journal of Neuroscience. 22(21):9305-19.

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Panda, S., Poirier, G.G., Kay, S.A. tej defines a role for poly(ADP-ribosyl)ation in establishing period length of the arabidopsis circadian oscillator. (2002) Developmental Cell. 3(1):51-61.

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Panda, S., Antoch, M.P., Miller, B.H., Su, A.I., Schook, A.B., Straume, M., Schultz, P.G., Kay, S.A., Takahashi, J.S., Hogenesch, J.B. Coordinated transcription of key pathways in the mouse by the circadian clock. (2002) Cell. 109(3):307-20.

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Panda, S., Hogenesch, J.B., Kay, S.A. Circadian rhythms from flies to human. (2002) Nature. 417(6886):329-35. DOI: 10.1038/417329a

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Covington, M.F., Panda, S., Liu, X.L., Strayer, C.A., Wagner, D.R., Kay, S.A. ELF3 modulates resetting of the circadian clock in Arabidopsis. (2001) Plant Cell. 13(6):1305-15.

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Harmer, S.L., Panda, S., Kay, S.A. Molecular bases of circadian rhythms. (2001) Annual Review of Cell and Developmental Biology. 17:215-53. DOI: 10.1146/annurev.cellbio.17.1.215

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Más, P., Devlin, P.F., Panda, S., Kay, S.A. Functional interaction of phytochrome B and cryptochrome 2. (2000) Nature. 408(6809):207-11. DOI: 10.1038/35041583

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Strayer, C., Oyama, T., Schultz, T.F., Raman, R., Somers, D.E., Más, P., Panda, S., Kreps, J.A., Kay, S.A. Cloning of the Arabidopsis clock gene TOC1, an autoregulatory response regulator homolog. (2000) Science. 289(5480):768-71. DOI: DOI: 10.1126/science.289.5480.768

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